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Aging of Human Muscles

Employing a fruit-fly model, the researchers discovered the organism’s longevity was affected by the types and amounts of amino acids taken in, with the amount of other nutrients having little effect.


Irina Conboy, from the University of California, Berkeley, and colleagues have identified a critical biochemical pathway linked to the aging of human muscle. By manipulating it, the researchers were able to restore the muscle’s ability to repair and rebuild itself, offering hope for injury repair and antiaging techniques in the future.

The team studied samples of muscle tissue from nearly 30 old and young healthy men who participated in an exercise physiology study and determined that the ability of adult stem cells to repair and replace damaged muscle tissue is governed by the molecular signals they get from surrounding muscle tissue, and that those signals change with age in ways that preclude productive tissue repair.

The team concludes that the “aging of human muscle maintenance and repair can be reversed by youthful calibration of specific molecular pathways.” They are hopeful: “This provides promising new targets for forestalling the debilitating muscle atrophy that accompanies aging and perhaps other tissue degenerative disorders as well.”

Balance of Dietary Protein Key to Longer Life

While research has proven that dietary restriction extends healthy life span in an array of organisms, Richard C. Grandison, from University College London, and colleagues have found that a balance of amino acids, the building blocks of proteins, is essential for reducing disease while increasing longevity.

Employing a fruit-fly model, the researchers discovered the organism’s longevity was affected by the types and amounts of amino acids taken in, with the amount of other nutrients having little effect. The results were so dramatic that the team concludes: “In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction… through a suitable balance of nutrients in the diet.”

—Dr. Bob Goldman
www.WorldHealth.net

Editor’s note: For the latest information and research on health and aging, subscribe to the American Academy of Anti-Aging Medicine e-zine free at WorldHealth.net.

Dr. Robert M. Goldman MD, PhD, DO, FAASP has spearheaded the development of numerous international medical organizations and corporations. Dr. Goldman has served as a Senior Fellow at the Lincoln Filene Center, Tufts University; as an Affiliate at the Philosophy of Education Research Center, Graduate School of Education, Harvard University, He is Clinical Consultant, Department of Obstetrics and Gynecology, Korea Medical University; and Professor, Department of Internal Medicine at the University of Central America Health Sciences, Department of Internal Medicine. Dr. Goldman holds the positions of Visiting Professor, Udayana University School of Medicine, Indonesia; Visiting Professor, Huazhong University of Science & Technology Tong Ji Medical School, China; Visiting Professor, The Wuhan Institute of Science & Technology, China; Visiting Professor at Hainan Medical College, China; and Visiting Professor, School of Anti-Aging, Aesthetics and Regenerative Medicine, UCSI University, Malaysia. Dr. Goldman is a Fellow of the American Academy of Sports Physicians and a Board Diplomat in Sports Medicine and Board Certified in Anti-Aging Medicine. Dr. Goldman is a Fellow of the American Academy of Sports Physicians and a Board Diplomat in Sports Medicine and Board Certified in Anti-Aging Medicine. He has overseen cooperative research agreement development programs in conjunction with such prominent institutions as the American National Red Cross, the US National Aeronautics and Space Administration (NASA), the Department of Defense, and the FDA's Center for Devices & Radiological Health.

Dr Goldman was awarded the 2012 LifeTime Achievement Award in Medicine &Science. Dr. Goldman is the recipient of the 'Gold Medal for Science, the Grand Prize for Medicine, the Humanitarian Award, and the Business Development Award. He received honors from Minister of Sports and government Health officials of numerous nations. In 2001, Excellency Juan Antonio Samaranch awarded Dr. Goldman the International Olympic Committee Tribute Diploma for contributions to the development of sport & Olympism.

In addition, Dr. Goldman is a black belt in karate, Chinese weapons expert, and world champion athlete with over 20 world strength records, he has been listed in the Guinness Book of World Records. Some of his past performance records include 13,500 consecutive situps and 321 consecutive handstand pushups. Dr. Goldman was an All-College athlete in four sports, a three time winner of the John F. Kennedy (JFK) Physical Fitness Award, was voted Athlete of the Year, was the recipient of the Champions Award, and was inducted into the World Hall of Fame of Physical Fitness. Dr. Goldman was awarded the Healthy American Fitness Leader Award from the President's Council on Physical Fitness & Sports and U.S. Chamber of Commerce. Dr. Goldman is Chairman of the International Medical Commission overseeing sports medicine committees in over 184 nations. He has served as a Special Advisor to the President's Council on Physical Fitness & Sports. He is founder and international President Emeritis of the National Academy of Sports Medicine and the cofounder and Chairman of the American Academy of Anti-Aging Medicine (A4M). Dr. Goldman visits an average of 20 countries annually to promote brain research and sports medicine programs.

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