Resolution is the final stage of the inflammatory response, when restoration of tissue occurs. Failure may lead to chronic inflammation, which is speculated to contribute to the pathology of Alzheimer’s Disease.
Marianne Schultzberg, from Karolinska Institutet in Sweden, and colleagues analyzed cerebrospinal fluid from 15 men and women with Alzheimer’s disease, 20 subjects with mild cognitive impairment and 21 control participants. They also analyzed brain tissue from 10 Alzheimer’s patients and 10 controls.
They assessed the presence and relative levels of specific inflammatory molecules and receptors involved in the resolution pathway—including specialized mediators—and observed alterations in their levels that were then correlated by standardized mental assessment to the cognitive decline characteristic of Alzheimer’s disease.
The researchers submit that the omega-3 fatty acids may address the resolution pathway dysfunction and thus may be a promising non-drug therapy.
Wang, X., et al. (2014). Resolution of inflammation is altered in Alzheimer’s disease. Alzheimers Dement. Published online February 12.
—Dr. Bob Goldman
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