Myostatin is the name of a protein that causes muscles to waste away. Finding a way to stop myostatin from atrophying muscle mass has become something of a quest for nutrition researchers. While no one has found that single magic bullet, research published in the Journal Of The International Society Of Sports Nutrition shows that a combination of leucine, creatine, and HMB can slow down myostatin’s negative influence on skeletal muscle. In the experiment, the three supplements stimulated the activity of a gene called Akirin-1, which, in turn, interfered with myostatin. Further research is needed, but scientists feel that creatine had the strongest positive effect. However, HMB and leucine are also thought to be important for affecting myostatin, as each one stimulates muscle growth via a different pathway.